Related StoriesDISC-1: schizophrenia's Rosetta Rock gene? An interview with Professor Kevin FoxNeurological screening accessibility and affordability: an interview with Dr Joseph HigginsNHS hourglass framework holds back development of support workforce The Hill: Advocates For Mental Health Have Momentum After Conn. Massacre The mental-health community has begun a major lobbying effort for federal government action in response to last Friday's college shooting in Newtown, Conn.Sequencing of genes encoding other members of the hedgehog pathway revealed no nonsynonymous sequence alterations in suppressor of fused homologue or SMO . Discussion We describe a patient with advanced medulloblastoma that had been refractory to multiple prior therapies. The tumor had an extraordinary, although incomplete, and fast, although transient, response to inhibition of the hedgehog pathway with GDC-0449. To your knowledge, this record marks the first demonstration that an inhibitor of the hedgehog pathway could cause regression of medulloblastoma. The regression is normally notable due to the tumor burden and the degree of metastasis in this affected individual, with substantial soft-tissue and bony-cells involvement and significant bone marrow compromise clinically, and underscores the primary role that the hedgehog pathway performed in maintaining and traveling the growth of this patient’s tumor.