From the age of 2 years, however, he has experienced unusual drop attacks. She stated that whenever Jack was running and excited around, he would suddenly end rigid and then fall backwards. By the right time a grown-up had run over to choose him up, he had recovered and seemed in any other case normal. There have been no postictal phenomena. His mother primarily thought Jack was performing, but over time realised that he was not doing it voluntarily. Jack have been referred six months to a neurologist and had undergone an EEG previously. His mother have been educated that he was not having seizures.Campbell, M.D., Jer-Ming Chang, M.D., Hung-Chun Chen, M.D., Jun Oh, M.D., Christian Faul, Ph.D., M. Amin Arnaout, M.D., Paolo Fiorina, M.D., Ph.D., Vineet Gupta, Ph.D., Anna Greka, M.D., Ph.D., George W. Burke, III, M.D., and Peter Mundel, M.D.1 The glomerular filtration barrier consists of the glomerular capillary endothelium, the glomerular basement membrane, and specialized cells, the podocytes, that serve as a final barrier to urinary lack of plasma proteins.1 Disrupted podocyte function damages the kidney filtration system, leading to proteinuria and, in a few circumstances, the nephrotic syndrome.1 Proteinuria is common to a heterogeneous group of kidney diseases, including minimal-switch disease, FSGS, membranous nephropathy, and diabetic nephropathy, all of which affect an incredible number of persons worldwide and frequently result in end-stage renal disease .1 Specifically, primary FSGS and also recurrent FSGS after kidney transplantation remain largely untreatable, resulting in ESRD and, after transplantation, to allograft loss.3 B7-1 is induced in podocytes in a variety of animal types of proteinuria.4 Podocyte B7-1 expression isn’t evident in normal individual kidney podocytes but is situated in patients with certain glomerular diseases.