March 9, 2018 Women who had large blood circulation pressure and experienced a severe headache were 17 times more likely to experience pregnancy complications, while having no history of head aches raised the chance fivefold, the study found. The findings were published online Aug. 19 in the journal Neurology.. Severe Headache During Being pregnant May Signal Trouble: – THURSDAY, Aug. 20, 2015 – – A severe headache can often be a warning indication that a pregnant female and her fetus are in peril, researchers report. Headaches during pregnancy are quite common, but it isn’t easy to distinguish between a recurring constantly, preexisting migraine condition and a headache the effect of a pregnancy complication, business lead author Dr.Dosage reductions were allowed as specified by the process and are referred to in the Supplementary Appendix. End Points and Assessments The principal end point was progression-free survival. The primary comparison was between MP and MPR-R. A 50 percent improvement in progression-free survival was regarded as clinically relevant. This scholarly study had not been designed or powered to assess overall survival. Secondary end points included overall survival, response rate, time to response, duration of response, response quality, and adverse events. Responses to treatment and disease progression were assessed with the use of the European Group for Bloodstream and Marrow Transplantation requirements,12 and an excellent partial response was defined based on the International Uniform Response Criteria for Multiple Myeloma .13 Serum and 24-hour urine samples were collected at baseline and every 28 days for 3 years and every 56 times thereafter until completion of the double-blind stage of the trial.