February 26, 2018 We found that cannabis users who bring a particular variant in the AKT1 gene acquired a two-fold increased probability of a psychotic disorder and this improved up to seven-fold if indeed they used cannabis daily, explained the authors. Our findings help to explain why one cannabis consumer develops psychosis while his friends continue smoking without problems. While the AKT1 genotype does not rise to the amount of a clinically useful test of the risk for cannabis psychosis, it can show that this source of psychosis risk includes a genetic underpinning, commented Dr. John Krystal, Editor of Biological Psychiatry. This advance also points to cellular signaling mechanisms mediated by Akt1 as being relevant to the biology of cannabis psychosis. This may suggest research directions for novel therapeutics for cannabis psychosis.Since the rate of death from malaria was low, we would not expect to have the ability to detect a reduction in the rate of death from any cause unless RTS,S/AS01 also provided protection against coexisting illnesses and the associated deaths. We attribute the low malaria-specific mortality in this trial to the advanced of access to high-quality care provided at study services. The low malaria-particular mortality is unlikely to be due to misclassification of moderate malaria as severe malaria. Kids who were categorized as having serious malaria had objective scientific markers of serious disease, and nearly fifty % had two or more markers. Approximately 3 percent of children with scientific malaria and 35 percent of these who had been hospitalized with malaria had been classified as having severe malaria, in keeping with reported estimates.27 At the final end of the analysis, a formal analysis of vaccine efficacy against death shall be conducted.