January 24, 2018 Beryl P. Gladstone, Ph.D nizagara wikipedia ., Sasirekha Ramani, Ph.D., Indrani Mukhopadhya, Ph.D., Jayaprakash Muliyil, M.D., Dr.P.H., Rajiv Sarkar, M.Sc., Andrea M. Rehman, Ph.D., Shabbar Jaffar, Ph.D., Miren Iturriza Gomara, F.R.C.Path., James J. Gray, F.R.C.Route., David W.G. Dark brown, F.R.C.Path., Ulrich Desselberger, F.R.C.Path., Sue E. Crawford, B.S., Jacob John, M.D., Sudhir Babji, M.D., Mary K. Estes, Ph.D., and Gagandeep Kang, M.D., Ph.D.: Defensive Effect of Natural Rotavirus Infections in an Indian Birth Cohort Group A rotaviruses are the leading cause of dehydrating gastroenteritis in small children worldwide, and rotavirus gastroenteritis results in more than half a million deaths each year. Therefore, we performed a candidate-gene analysis, like the genes of the key enzymes involved in vitamin D metabolism . Although conventional sequencing of the coding regions of CYP27B1, FGF23, and KL didn’t reveal pathogenic mutations in individuals from both cohorts, the sequence analysis of CYP24A1 yielded missense and nonsense mutations in the homozygous or compound-heterozygous state in Patients 1.1 to 7.1 . Cosegregation analysis was appropriate for autosomal recessive inheritance in all families. In Patient 8.1, only 1 pathogenic mutation was identified, which raised the possibility of a second pathogenic mutation outside the coding area or a heterozygous deletion that had not been detected by sequence analysis.