The analysis population was middle-aged or old; most patients were non-Hispanic guys, and a lot more than 35 percent of the patients were obese . A total of 11 percent of the participants had three or more adenomas at baseline, and 18 percent had a number of advanced adenomas. There have been no material variations between treatment groups with regard to personal characteristics . Fifteen patients who underwent randomization and had been included in the evaluation were later found not to have met all eligibility criteria . Adherence to the scholarly study Procedures The reported adherence to colonoscopy was excellent. Only 67 participants didn’t have a colonoscopic examination with associated histologic data at least 1 year after randomization, and 104 participants dropped out from the study, were lost to follow-up, or died; this left 2088 individuals in the analysis .Current risk stratification is founded on clinical variables primarily, immunophenotype, detection of sentinel cytogenetic or molecular lesions, and early response to therapy.1 However, a substantial proportion of patients who have a relapse haven’t any known poor-risk factors at the proper time of diagnosis. We used high-resolution, genomewide copy-number evaluation to identify genetic lesions connected with clinical outcome.