AS Orthopedic Causes The exact reason behind ankylosing spondylitis remains unknown. A possible genetic link exists, as the chance of developing ankylosing spondylitis or any other seronegative spondyloarthropathy increases when a family member has the condition. Ankylosing spondylitis and the other spondyloarthropathies have also been linked to a particular protein, HLA-B27, in someone’s blood. If this protein is present, the chance of developing ankylosing spondylitis is multiplied 10 times. The precise role this protein plays in the development of ankylosing spondylitis is normally unclear.So very bad is the issue that seven out of ten Britons are tweeting, poking, surfing and composing on each others’ walls rather than going to sleep. Furthermore 18 percent of adults send a daily night-time tweet to their fans and one in five Britons capture through to tweets from their preferred celebrities and friends in bed. On average every night Britons are spending 16 minutes in bed socially networking with pals – with the peak chatting time being 9.45pm.